Okay, I did some interweb searching and came up with the following:
In Nintendo Power:
- Guybrush and Elaine are "cemented" as the power couple of the Caribbean. This means Morgan loses or leaves somehow.
- Puzzles using items from past chapters (whether forgotton or annoying) ie: the parrot.
- This is the part that Ron Gilbert helped craft most (YES PLEASE)
- Supposedly really cool.
Okay, also from the fact that we know Guybrush is cured while having the hook, gets his hand back (based on screenshots for Chapter 4) and it was the left hand that he lost, the following image shows him having MAJOR pox issues. Could HE be the Pirate God?