Guybrush: Only slightly, I think. Perhaps no beard and no HUGE dangling bang in front, new coat, etc.
MORGAN: For the love of god make her look more like a hardened woman ie: Kate Krebbs. She looks like Fairly Oddparents right now and I personally think she just looks silly in the game. Her eyes are the size of Elaine's head! WAY too cartoony, even for MI.
Elaine: She's pretty good how she is.
LeChuck: Fix the teeth / mouth, maybe taller and a bit thinner, more defined eyes that have both eyeball and pupil. I highly preferred Chapter 5 version to earlier demonic version, that's for sure.
Voodoo Lady: Older, taller, less EMI more CMI.
Stan: Bigger eyes, otherwise fine
Winslow is fine, if he comes back for another season.
Murray, also fine, exactly how I imagined him in 3D.