Was just playing Episode 2 for the first time, went to the TV Station, then to Bosco's - while in Bosco's, had the cinema play which meant I should leave the store (trying to avoid spoilers here), clicked on the door to leave, and my cursor disappeared! No buttons worked except for Alt-F4, so I couldn't save my game. Weird thing is the graphics kept moving as per normal (but I think Max stopped moving, he was off-screen and didn't come back) and the sound kept playing.
Anyone else seen this? Do the devs know about it?
There goes 15 minutes of my life! :P