I've just discovered an interesting option of my nVidia card. Amongst the color correction options is a slider labeled Digital Vibrance. Increasing this (it was off by default) greatly increases the intensity of all colors, contributing to a much more colorful and cartoony feel. From what can tell in briefly trying it out with ep4 it suits Sam & Max especially well, and I think I'm going to replay all episodes just to reexperience the art in renewed splendor.
If you've got an nVidia card, you should definitely give this a shot. And if you have any other brand it may be worthwhile to look for a similar option (I've got no idea if this is in any way unique to nVidia).