I got the Sam and Max DVD in the mail the other day and quickly set about to installing it (for some reason the downloadable version of the episodes stopped working for me), only to find that the DVD version also fails to start.
It seems like it's passing the CD-check for SecuROM, but once it gets past that I get an unhandled exception from the executable (caught by the Visual Studio 2005 debugger):
"Unhandled exception at 0x004c6a6d in SamMax101.exe: 0xC0000005: Access violation reading location 0x0425cb8c."
[*]Core 2 Duo E6600
[*]ATI Radeon X1900XTX
[*]2x1GB Crucial DDR2 PC2-5300 667MHz RAM
[*]Intel DP965LT Motherboard
[*]Creative Audigy 2 "Value"
Results from dxdiag attached.