This may have already been discussed, but I couldn't see anything on it. It seems that the general consensus is that Lee's family are dead. Am I missing something that did confirm this? If I am, then I do apologise for asking the question.
As far as I can see though, we know Lee's brother was infected and somehow came to be trapped under what I think was a telephone pole. We see a lot of blood in the back office, and clear signs of struggle. But couldn't this blood be Lee's brother's blood? Maybe he came to his parents rescue, and they managed to escape? I think Lee actually says something along the lines of "If you were here, I figure you died to saved them. I've gotta assume that's what happened." (This obviously isn't word for word, but this was the gist.)
So, providing I'm not missing something, what effect could this have on Lee in later episodes should we encounter them? We may not, and probably won't, get further clarification on this -but it would be interesting if there was a decision to choose between Clem and his family. His responsibility to Clem against the guilt of not being there for his parents and indeed his brother. Not sure how I would handle such a choice.