As some of you may know, connecting a Wiimote to a PC is easy. You just need a Bluetooth reciever and proper software to handle the Wiimote motion sensor data. This way you can use your Wiimote instead of a mouse in FPP games, etc. And since Sam & Max is controlled with a mouse, I gave the Wiimote mode a try.
P.S. - I imagine controlling a point and click adventure would be quite enjoyable on Wii. Plus the "minigames" like the driving, where you could tilt your remote to turn left or right... Shooting would be fun too. But then again I'm not so sure that people who buy a Wii would want a point and click adventure game. At least not to make proper sales.