These are my speakers.
Sam & Max 201 worked fine on my two speaker setup, but when I got a new 5.1 speaker set up, things weren't as smooth.
When another sound is being played over the music (for example foot steps, speech, gun shot, etc) the rear two speakers start going jumpy, but resume playing the background music when the sound is over.
Sort of like this...
Here's a sound clip/movie I recorded to show what I mean: http://files-upload.com/files/681535/Untitled.WMV
Remember: this is only the two rear speakers. The other three work fine.
I'm sorry this doesn't really make any sense, its's due to my lack of ability to explain things well. :p