I think everything about the new Sam and Max game looks great, but I just read this preview at ShackNews and this disturbed me: "This game opts to filter the player's interactions with the world down to a context-sensitive click interface, rather than giving a list of verbs that the player can execute. Clicking on a person is likely to initiate a conversation, while clicking on an item may cause Sam either to examine it or pick it up."
Half the fun of adventure games is figuring out on your own what you're supposed to be doing. When you are held by your hand and guided through the whole thing, it becomes less an interaction and more just watching something play itself. I think this is probably being done so as not to intimidate those unfamiliar with adventure games, but I say, why not have both options available? Simply have an option that either the cursor automatically changes to whatever it is above, or the player manually cycles through the different cursors (say, with the right click). Those that are more experienced can go to the settings and choose to manually cycle -- and for those that aren't, it will be set-up initially to be automatic.
Now, maybe that wasn't done because of all the things the character has to say in response to things he can't do. But then, why not just record one broad line of dialogue? "I don't want to do that" or something (like Hoagie in Day of the Tentacle.)
This is such a simple thing, but it really would limit the fun of the game, I think, not to have the ability to do this manually.