I got this idea while writing a post in another thread. Lets point out some of the symbolism in The Walking Dead
In another thread I said that Clementine having the stranger's pistol showed a sense of maturity. It means that she is letting go of her childish ways and she his learning from her mistakes. If you got her to shoot the stranger, it could also mean that the gun is a symbol of her loss of innocence, sense that was the first living person she shot.
Another symbol I found is a big one, it's heavily used throughout the game. Clementine's hat is a symbol for hope. Clementine says early in the game it's from her dad, and it is one of the only few things she has that reminds her of her parents. This could reflect Clementine's hope that her parents are alive and that everything will go back to normal. When Lee finds Clementine's hat near when he gets bitten, he gets walker blood stained on it. This could mean the symbol turned into fear. I say this because Lee hopes he can make it to clementine on time but yet is fearful of when he will turn.
EDIT: I changde denial into fear after thinking about it
That's all I got, let me know if you disagree with anything I wrote here, I love stimulating debates. Also if you have any other symbols you'd like to point out, do so!