After playing the game without any problems during my first session, I find I'm no longer able to play due to a crash long before gameplay.
When starting the game, I've just reached the Gametap splash screen when the screen pauses for a few seconds. Then a loud 'tap' is heard, leading to a continuous loop of ambient city sounds. The computer locks up here before the Telltale Games logo is even displayed!
The only settings change I made was upping the resolution to 1024X768 (my default desktop rez). If that was the problem, the crash makes it impossible to undo. I fear that deleting the files and starting over may be my only recourse now, but it's too risky without further advice.