This discussion may contain spoilers!
I have 4 of 6, and am borrowing from another thread to streamline
1: Use the phone right after the game starts, you'll phone THE COMISSIONER from Sam & Max
2: Click on the stick before you pluck the flower, you'll hear that Dangeresque framed the LORAX for murder.
3: Talk meanly to Bubs when he's in prison. Does get you a point, but I can't figure out what the celebrity name is
4: Show up at the club. Seems automatic, but if you have Perducci Shuffle the cards, you will get a SAM & MAX "EMBARASSING IDOL" card
5: Its not totally confirmed yet, but its at the Space station
6: In extended play, click on the cool car, you will see that the voice of the autopilot was provided by BILLY DEE WILLIAMS.