Does Telltale is going to make a game of those underrated genres? Think about a mythical book or series of books (Ender Saga by Orson Scott Card? Hyperion?), or developing a story in collaboration with some really good science fiction writer.
I think it could be hand drawn high quality 2D or very well done 3D in my opinion.
Think about a coproduction with some company or developer doing adventure games too.
I'm happy if it's for Wii too :)