I don't know if anybody else encountered this, thought I'd share:
During gameplay I've switched to another program for a minute; when I switched back to the game, Guybrush lost his walking animation, although I could still move him (It looks like he was moving on a treadmill). When I went to a new location, everything worked fine again. Is this a known issue?
(Also, when I switched programs again a while later it didn't happen again, so I don't know if the switching caused it or not...)