There's one thing I noticed while playing The Last Resort - in some cases (seemingly independent of the location), there are random pops in the speech. It doesn't seem to affect the music or the sound, only the speech.
I know these problems are usually remedied by lowering the graphics settings - I couldn't really try that as the pops are not reproduceable. Is it possible that my desktop VGA (9600GT) isn't strong enough to handle level 9? There was no such problem with Fright of the Bumblebees, not once.