I guess I speak for several ToMI fans when I say, that the Inventory controls could be improved.
Here are my proposals based on ease of usability.
Right Mouse Button (RMB) to open the Inventory
It can be used to close it, but not to open it. If the hand lies on the mouse it is probably more convenient for the most people to press the RMB than the scroll wheel.
Combining items by dragging one onto the other
This would make combining a lot easier and faster. I found the current combining system so annoying, that i didn't try a lot of combinations if i thought they might be nonsense. It is however not always obvious what can be combined, which is clearly part of the puzzle.
Therefore a more efficient way such as dragging would be appropriate, and would encourage players to try more combinations.
Examining by double clicking an item
Dragging an item to the magnifying glass or turning on the examining mode are both quite inefficient, similar to the combining. Double clicking would speed up examining multiple items one after the other.
I think that's it. Those controls could coexist with the current ones for people who prefer those. At least i don't see any conflicts. I hope you like the ideas and are willing to implement them, if others agree that they would improve the gamers experience.