I'm having some serious problems with TMI 5. Intermittently after either 5 minutes to 50 minutes of play, the game will bring my system to its knees and freeze everything. Only a hard reset will get me out of it. The game runs smoothly and awesome otherwise. I've had no problem with Chapters 1-4, so this behavior is odd to me.
I'm on Windows 7, but I've also tried it on Windows XP - same problem. I've got a P4 3.0 GHz, 2 GB RAM. ATI RADEON X800 GTO. Playing in windowed mode at 720p resolution (1280x720). Graphics quality 6. Runs very smoothly, but sometimes suddenly it just crashes freezing everything! This makes me sad.