i too ve been getting almost non-stop crashes with sam & max season 3 (still, i've played through the season 3 times now even with the crashings). Not sure this happens to anyone else, but the game will freeze up, often during loading of a scene or dialog or menu screen, and when i load up my save upon reopening the game, it tells me on my save game that Sam & Max are on "Flotsam Docks." As far as I know, this isn't supposed to be any sort of crazy Sam & Max/TOMI crossover, as when the save loads i'm greeted with a black screen but still the cursor and ui.
Damn, and here I was hoping to see Sam & Max launch the screaming narwharl in search of LeChuck & Elaine. Admit it, you know you'd play that.