Uhhhhh...something tells me Ice Station Santa shouldn't be using this much memory:
I first noticed the problem when the game was lagging horribly after a couple hours of gameplay--I went into the task manager and found out it was using over 900MB of RAM. I saved the game, quit, and rebooted--everything was fine. But I kept an eye on the memory usage, and it kept increasing, especially when I'd move to a different area in the game (ex., going from the neighborhood to the North Pole sometimes caused jumps in memory of over 100MB). When it got back up to 900+MB again, the lag kicked back in--I switched to a lower, non-widescreen resolution (1024x768; earlier I was playing at 1280x720) and the lag resolved, but the memory usage definitely didn't! I let it run for a little while longer, and the picture above is what resulted.
For what it's worth, I do play in windowed mode, and do have some tasks running in the background (IM client, Firefox, etc.) because I'm a horrible multi-tasker, but they've never given me any trouble with Sam & Max (or any other game, for that matter) before.
And if it helps at all, my computer stats are:
Windows XP SP2
Pentium IV 3.2Ghz (w/hyper-threading)
ATI Mobility Radeon X600 (256MB RAM)