First play-through today (via GameTap). No problems, until I tried to hand the application to Sybil by dragging it from the inventory to her (didn't think to just talk to her...)
Went to a black screen for a while, then exited to GameTap. Loading the auto-save results in the same black screen. (No sound, no drive activity.)
And of course, I didn't save the game at all manually, beause I hadn't intended to play for more than a few minutes. :p
Anyway, is it possible to get at the save files from the GameTap client [before I try and start a new game and write over it]? (I'm guessing no...)
Guess the moral of the story is save. Often.