What if Telltale created an episodic game revolving around the Penny Arcade series?
Unlike "On the Rain-Slick Precipice of Darkness", it would be set in the main present day universe with Tycho, Gabe, Div, Annarchy, Charles, Frank, the Fruit Friend and others. Story wise, it could involve one of the characters in some sort of trouble (presumably Gabe) and would have the player supposably controlling either Tycho and Gabe across the different locations.
Like the comics, it would feature the usual shananigans and a whole heap of video game and pop culture references. Gameplay would be similar to that of Sam & Max and could feature Kid Beyond to return voicing Tycho.
Of course with Telltale's current development, this sort of thing couldn't happen for a while.