Hothead just announced a new game based on Hitchhikers Guide to the Galaxy. They set up a small teaser site (is that the voice of the original Arthur Dent, Simon Jones?): http://www.thenewhitchhikersguide.com/. Not much is known about the title just yet, but with E3 so close it wouldn't surprise me if more information is coming very soon.
On the one hand I'm very happy that there's a new Hitchhikers game, but I'm not sure if Hothead is the right company for it. What a Hitchhikers game needs, above all, is extremely good writing. I'm not sure if Hothead has writers that can come near Douglas Adams's level. Their games are pretty fun, but the writing (I guess I can only look at Deathspank, because every word of the Penny Arcade games was written by Jerry Holkins) is, in my opinion, pretty bad. And even if you enjoy Deathspank's humor, it's nothing like the kind of comedy you'll find in the Hitchhiker radio plays/books.
Anyway, maybe I'm being too pessimistic. I'm happy that this game is coming out at all, so let's stay positive for now.
Oh, and if someone from Telltale is reading this: get the Discworld license before Hothead gets their hands on it. Terry is still alive, and there are more movies and a television series coming soon, so get it before the rest of the videogame world realises what a perfect franchise it is.