Actually, a series that might better fit the serialized structure of Telltale game's development might be Police Quest! So after giving us the pseud-mideviel period in KQ, maybe they could give us a new adventure of the blue knights of Lytton?
One thing that would make it work well, was that PQ series was split into 'days', and you really only had access to a few areas each day! Clues would lead you to new areas, and there was the occasional car chase, and arrest in the early games.
Thus Telltale could easily split the game up into seperate days. They could have the overworld map of Lytton (or other cities) be the way you get around to the areas that are required. But you would have to learn about the areas you need to get to during your investigation or from radio dispatches!
The central main area, like in the early Police Quests would be the Police Station! That would appear in every chapter!
Plus the game would allow for Telltale to to tell a gritty story, but with some humor here and there; Death messages, stuff like the newspaper articles about King Graham and Daventry seein the first and second game (which they could make references to Telltale's KQ series), the software collections installed on the Police computer systems, and other stuff akin to the "Grimlin", (a humorous series of gags that occured in PQ1), and mixed into random conversations in the game with other people in the force or answering machine messages received dialing in random telephone numbers (or numbers written in the records)!
Another good series that could be split up into separate games/chapters, but reuse a limited space is the Laura Bow series.