This discussion may contain spoilers!
This hasn't happened until today...
Since I felt in the mood to kick some Hugh Bliss butt, I launched Episode 106 from the Telltale DVD. However, the game is locking up when Sam gets control of the saw at the part where you're supposed to saw off the Lunar Lander leg. This didn't happen until today. The only huge recent changes I've made are:
Uninstall QuickTime 7 and installed QuickTime 6.3 so Myst and Riven would display properly
Finish Episode 205
Intel Centrio 1.5 GHz Processor
128 MB Intel 915 Chipset (my graphics card is definetely not the culprit, the game worked fine [I even beat Episode 106 2 times before])
1 GB of RAM
Windows XP SP2
Tried 800x600, still froze, along with my usual 1024x768 resolution