It seems whatever incompatibility with Windows 8 Pro 64-Bit that's going around has hit me as well. I've tried running the game in various combinations of compatibility modes with and without running as administrator, unplugged my Xbox wireless controller, Logitech G13, Logitech G19, and offering a sacrifice to Odin...with no success.
Processor: AMD 1090T BE
GPU: Gigabyte Radeon HD 7950 3072MB
OS: Windows 8 Pro 64-Bit (System Builder, not upgrade)
Urge to kill: Rising.
I'd love to hear a fix, but would gladly accept an official "We know this is a problem and we're working on it." since this doesn't seem to be an isolated problem.