In episode one, the game freezes and crashes without fail during a certain cutscene, sometimes locking up my entire system and requiring a hard shutdown. It is in the cutscene that transitions Lee and Carly to the motel. This makes completing episode one impossible.
Processor: 2.53 GHz Intel Core 2 Duo
Memory: 4 GB 1067 MHz DDR3
Graphics: NVIDIA GeForce 9400M 256 MB
Software: OS X 10.8.1 (All updates applied)
The game has run relatively fine until this point and no combination of graphical settings has helped with the issue. I am most disappointed because some Google-fu reveals that this has been an ongoing problem with the Mac version of the game all the way back to April and seems to still go unaddressed.
I'm feeling pretty stupid for not investigating the issue before purchasing.