I have made a post about improving accessibility in the game for disabled people.
Since 90% of the game are dialogues, the game could have been very accessible for many people, especially in terms of mobility. But there are features that make it totally inaccessible to many people: no pauses to read the dialogue, have to make choices in very short time and some action scenes with quick time events.
I hope Telltales consider this issue important and add more options in the game to make it more accessible. Meanwhile this can help a lot of people that could not play it yet.
You can read it here:
http://www.videojuegosaccesibles.es/2013/01/the-walking-dead-mejorando-la.html (in Spansih)
http://translate.google.com/translate?sl=es&tl=en&js=n&prev=_t&hl=es&ie=UTF-8&eotf=1&u=http%3A%2F%2Fwww.videojuegosaccesibles.es%2F2013%2F01%2Fthe-walking-dead-mejorando-la.html&act=url (Google translated)
Or just watch this video demonstration: http://www.youtube.com/watch?v=Z4_qOAIBRKo