I'm thinking of a wild western game that is based on the Pony Express. You play a lone horse-riding delivery man that must survive hazards, such as rattlesnakes, cactus, stapeding bison, and indians, in order to deliver mail to a homestead. It'll be both entertaining and educational, like the game with the math loving kung-fu fighters.
If you dive in untreated pool water, a parasitic amoeba will enter through your nose and travels into the brain. The infection causes severe deterioration of the brain and spinal tissue, and you go into a coma and eventually die. Isn't that great?!