The new drivers worked! My mainboard is Asus P5W DH Deluxe with a dual2core processor. Now the drivers listed on Asus homepage is really old, so I've sendt them a complain about that.
To others having the Asus P5W DH Deluxe mainboard, do these steps
1. Goto http://www.realtek.com.tw/downloads/
2. Select the High Definision Audio Codec Software
3. Audiochip is named ALC880 and the driver is version R1.47
4. Download and save it to a folder
5. Uninstall the old driver and reboot
6. Install the new, and reboot
Keep up the good work, Sam'n'Max is a great game!