So jumping to a different topic that is along similar lines: How about keyboard support for dialog selection like the old monkey island games used to have? I admit, I'm lazy, and at times I've reached over and hit '1' only to remember that it didn't do anything so I'd have to move my mouse all the way over to the selection box and then painstakingly click on the selection... you understand the grueling task I'm speaking of here.
Seriously though, it would be a nice feature in the PC version of the Telltale Engine. Its been something I have wanted since the first Sam 'n Max. I know it wouldn't work well for Wii-Ware or XBLA. Admittedly I'm still slowly playing through Strong Bad and I haven't tried Wallace and Gromit so I'm not sure if you have perhaps come up with something but I thought I'd ask anyway.