Yes, you can. From our activation FAQ
Q: Do I need an internet connection to play your games?
A: An internet connection is needed to download our games, as well as to activate them. This includes activation of the CD versions of our Bone games.
If you don't have an internet connection, the CD versions of the Bone games can be activated manually. To do this, click on Activation Support at the bottom of the first game screen. This will provide you with your computer's hardware fingerprint code. Send this code to our support team, along with your order number or some other information that will help us identify you (such as your first and last name, or the email address you used to place the order), and we will send back an activation key that allows you to activate the game manually.
The file you want to move over to your other computer is not the small "Download Sam & Max Now" file, but the bigger setup file that downloads when you run the small file. (First, uncheck the box that says to install immediately after downloading, and move the download location to somewhere that will be easy for you to find, such as the desktop.) You can also download this setup file directly from a number of mirror sites, such as 3D Downloads
. Once you install that file on your home PC, click Activation Support, send us the hardware fingerprint, and we'll send back an activation key.