I noticed a few things:
1) When you use the wishing well in the jungle, the screen flashes white and then transparent to show you looking like LeChuck.. I was wanting to skip this (I'd already seen it), so I pressed Esc right as the white flash was showing. I got the menu cursor and sounds, but the menu was covered with the white also.. my entire monitor was white. I pressed Esc a second time to return to the game, and the animation of the white fading out continued... nothing major, but you may want to undo any visual filters the game is currently showing when the menu is being accessed.
2) Using an item on an object in the world would about 50/50 leave that item attached to my "use cursor" or wipe it and make me reselect the object in my inventory. Not sure what the reason for either way was.. I prefer leaving it attached to my cursor to use again, myself.
3) I had the floating-not-walking Guybrush bug show up.. I think mine happened right after interacting with my inventory object on the carvings under the jail (Gromit!)