I really loved the puzzle where you had to do the Hula of Hades while riding a tricycle through a volcano, using items along the way to ensure you weren't burned to a steaming crisp.
But when you had to escape the bar filled with Angry Smelly Cursed Leper Gorilla Pirates by using the same tricycle on the clothesline to get across the rooftops, followed by having to signal for your horse by forcing a parrot in your inventory to swallow the Bullhorn of Singood? How could anyone figure THAT out? Worst puzzle in the series.
I quite liked the puzzle where you used Guybrush's bald spot caused by the singing fires from that evil juggling fire-breathing pirate clown you stole the tricycle from, plus Wally's lens, to blind the two-headed cyclops guarding the entrance of the caves where Lechuck had stashed Elaine's pirate ship. That one was fun, especially watching the cyclops fall off the cliff into the sea like Wile E. Coyote.