[CuriosTiger]

Originally Posted by The Commissioner

I don't think I have ever had to use any compatibility mode at all. Try turning off all compatibility mode settings and then install the patch update from LucasArts and try running the game:
http://www.lucasarts.com/support/update/monkey-4.html

Didn't work in 64-bit Windows 7. This did, however, work with the release candidate of "Virtual Windows XP" (which is basically XP in a VirtualPC VM).

I ran into another problem there -- it wasn't able to start in DirectX mode (maybe I need to install 100 DirectX versions on top of XP?)

It did start in OpenGL mode, and I was able to view the intro. After the intro, however, it went dark. Sound effects continued, but nothing was being displayed anymore.