Every time you win a game, you unlock a new set of card designs. The game then randomly selects a design out of those you have unlocked when new cards get dealed. If I remember correctly, you unlock two Telltale Hold Em logos, four cards with the faces of the other players, four cards with an item related to the four other players (a bottle of poison for Grandma Shaky, iron knuckles for Boris, a bottle of root beer for Harry, and a palmtree on a beach for Dudebrough), a card with mouse, one Dunk-card and two Dank-cards (3D Dank!). I might be forgetting a few unlockable cards, but I think that was it.
Anyway, sorry for going off topic. So yeah, we want more Telltale Comic-goodness!