I'm personally curious if we get to see De Cava again. I feel that he and the Voodoo Lady should talk things out, if that's the very least she can do. He might have been bananas from the very beginning, but she has done him wrong too. And I'd be happy to see a reunion.
Second thing, I'm curious about Guybrush's hand. What role will it play in the final unravelling?
"I do not require your trust, Threepwood! Only your... heroism."