I did the same thing again and it didn't happen.
However a crash of the same nature happened later in the game after I had "neutralized" Bosco's security system.
The music continued but the game was totally unresponsive, and the mouse was not moving in game. (But was moving on my second monitor.) However Ctrl-Alt-Del had no effect. (I have it set up to pop up task manager on my second monitor so I would see it even if the game was still full screen.)