While far from "major" in any way, you may be interested in The Real News
. They don't run ads or take subsidies because they don't want to be in anyone's pocket. And unlike your average news site they're all video and have professional journalists (it was started by journalists fed up with the usual media biases), many local correspondents, fairly in-depth interviews and big ambitions.
I won't say they're always neutral or correct, but they are
independent, know their stuff and show you things you won't often get in regular media. And with pretty good production values.