I had the first episode crash on me when I connected my bluetooth mouse while in game. The way TMI is setup, if it crashes you have to to do a hard reboot even if it doesn't take down the operating system because all the keys that would let you switch programs or use expose to get out of the game and kill the process do not work when the game is in its full screen mode.
Other mac games, like World of Warcraft for example, allow you to switch applications while in game so you are not locked out of your computer if it freezes and you can switch between the game and a guide for example. Is there any chance that TMI could be changed to work that way? It would be great if the problem was fixed in the next update.