I have the same problem on my Mac as light_rises. The game crashes at what I assume is the end of the intro sequence after I've finished the tutorial on Skunkape's ship. Same place every time. I guess I could try Boot Camp with the Windows version which always worked for the previous Telltale games.
Macbook Pro, running:
Mac OS X Version 10.5.8
Processor 2.4 GHz Intel Core 2 Duo
Memory 4 Gb 667 MHz DDR2 SDRAM