As long as it doesn't retroactively mess up the continuity I'm okay with that. Even if it's around Ben.
Really, at the end of Full Throttle, with the exception of Maureen the status quo is maintained. Ben is more or less where he was when the game began. At least, that's how I read it.
There's more that could happen to him. The plot and the conflicts don't need to carry over from the previous game, but there's a world here that can be further explored, and some of the concept drawings from the Payback sequel were looking to do just that.
And again, I feel compelled to reiterate that it is a world grounded in reality. No fantasy objects, no magical orbs, no time-travel. Because of this, everything has to follow a logical process and reasoning. I like that. I don't mind the zany and crazy like Sam and Max or Tales of Monkey Island, but I want to see if Telltale can keep this consistent with the previous game.