I'd love it to have all the best elements from the comics/Hit the Road/cartoon. However, in my mind the most important part is:
The relationship between Sam and Max
If the dialogue doesn't make us believe these guys are best buddies after about 3 lines then it's a failure. The thing I loved most about Hit the Road was the way the two main characters interacted with each other. Sam uses Max like a tool but he loves him like his good pal.
Such good friends, such insane happenings