I've had a massive re-think and re-read of this post. I won't take credit for the ideas, only for fleshing them out and making them more badass.
Guybrush and Murray
Papierwaite and Norrington
Strong Mad and The Cheat
Wallace and Gromit
Homestar Night with Subtitles
For fully balanced configurations, I'm working on an extensive list, which I shall upload when I'm done for scrutiny and ever-coveted internet points.
Life is like an adventure game: if you don't click, you don't get it