That is a good call. I think a good reference for a Dresden Files adventure game would be the Bladerunner adventure game that Westwood Studios did back in the day. What a sweet game...and it perfectly reflected the movie...and you could even shoot people in it! ^^
Point and click with guns...win.
I guess I say RPG becuse there actually is a Dresden Files pen and paper ruleset out there. And well...I think it might be fun to make your own wizard...or would-be wizard. Perfectly easy place to start the game too...McAnally's Pub! Since Dresden is the only real wizard that goes there...it'd be a great place for your character to start his quest...taking on small missions and such and gaining knowledge, training, and even your own spirit!
However the pub would be a great place for an adventure game too...as you could literally have Mac's own brewskies in your inventory. You could also talk to various people...and I would love to see Mac respond with "Ung" to everything that my character asked him.
Getting kinda off topic though. But man...Telltale...you guys should seriously consider the Dresden Files...that would be so amazing, but possibly too close to that Fables game maybe?
I could totally see the Vampire war kind of heading towards a zombie apocalypse in order to kind of wipe out humanity or perhaps the Fallen would use the fear and pain as a power grab in the heavens or something. I have only read the first five books so not sure what the overall storyline does.
But Dresden meeting Hershel...lawl.