I love Lee and Clementine, but maybe one season is enough to explore the two characters. I guess the need for continuing their story would be influenced by what happens in episode 5.
Otherwise, it would be neat to follow a new group in a different environment. Specifically, an environment beyond America. (Australia, England, India and so on.) I think would be interesting to experience environment specific scenarios. For example, a travelling Australian group might encounter a scratched up, bitten survivor in a rural town. The bitten survivor is vomiting and claims to be suffering from a Taipen bite. Do you believe the survivor and give them your last antivenom? Do you accuse the survivor of lying? Do you ignore them? etc. Fun. c: