Yea just like Hershel's son, during my 1st run there was less than 25% of players chose to save him over Duck.
(I didn't read the comics at that point, so I didn't know his "bigger role" in the comics)
After playing the game I decided to read a couple (actually not a couple but a lot) of the issues of the comic.. couldn't help to think people are like "Oh he's going to be taking that role in the comic anyways, why bother saving him" thus the result I saw.
Same applies to Lee or Clem here, wouldn't be nice if they appear in the comic before this game ends, or having characters in the game with players knowing "He/She will appear in issue XXX anyways"
Lilly is fine as long as we don't know what she's gonna react according to how we treat her, unlike Shawn's situation