Same problem here. I can't even get my game to load. I rebooted, uninstalled, reinstalled, disabled internet, anything you can think of. The only way I can even get it to run is running it in XP SP3 compatibility mode. Once it opens, it won't open full screen, I have to select full screen and reset all of my settings. The issue would end there except for the fact that all of my progress and savegames are now gone even though they are in the correct directory in My Documents folder.
Telltale- we dealt with the terrible release of this game, and now this? I couldn't play the game when it was supposed to be out, and now months later I am in the same spot. Step up your game.