It's odd that they mention how fluid the animation is... that is actually the issue I take with it. The facial close-ups in particular seem TOO fluid somehow, reminds me of Flash animation. I can't quite verbalise what it is, just feels "off". Maybe it's what you guys are saying about the character models not integrating well with the hand-drawn backgrounds.
Also, in the Kickstarter video (at 5:35) you see them hand-animating 2D drawings of George. If the characters are actually created as 3D models, is that bit just visual filler or something?
At any rate, it's going to look a damn sight better than the 3rd and 4th games.