Something that I think could be a huge "OMG" moment would be to...
Let Lee live through this season with Clementine and we start Season 2 as him. But the very first episode of season 2, he dies and we're forced in to the eyes of another survivor.
Probably won't happen. But it could be a helluva way to start a new season. Everyone is gearing up to be Lee and protect Clem. Then halfway through.... BANG. You become someone taking care of a mourning Clementine (barring she doesn't die at the end of this season.) Random food for thought.