Hopefully not by killing off important characters in ridiculous ways.
There ought to be more ways to further progress the story in interesting ways.
Maybe making Lee lose Clementine during a long period of time. And to finally in the last episode discover her in some state (bitten, turned, dead, alive, angry and so on) due to all the decision you've made throughout the game.
And based on that, Lee can make a choice depending on what has happened to Clementine.
That choice will be your final, and ultimately ending the game, and the Lee story arc.
Alternatively, we continue with Lee onto season 2, which I hope they do